Abstract
Skeletal muscle comprising approximately 40% of body weight is highly important for locomotion and metabolic homeostasis. The growth and regeneration of skeletal muscle are highly organized processes; thus, it is not surprising to reveal certain complexity during these regulatory processes. Recently, a large number of evidence indicate that microRNAs can result in obvious impacts on growth, regeneration and metabolism of skeletal muscle. In this review, recent research achievements of microRNAs in regulating myogenesis, atrophy and aging during exercise intervention are discussed, which will provide the guidance for developing potential applications of microRNAs in health promotion and rehabilitation of sports injuries.
Highlights
Maintaining the function of skeletal muscle is the prerequisite of keeping individual health and independent living during the whole life cycle [1]
This article summarizes the latest research achievements of microRNAs associated with skeletal muscle function, explores the functions and corresponding regulatory mechanisms of miRNAs in some physiological and pathological conditions, in an attempt to provide the reference for developing novel and effective intervention strategies for maintaining and improving the functions of skeletal muscle
This study indicates that the regulation mechanism of miRNA to PGC-1α may be different during acute and long-term endurance exercise
Summary
Maintaining the function of skeletal muscle is the prerequisite of keeping individual health and independent living during the whole life cycle [1]. Since a series of factors including neuromuscular disease, chronic disease and aging have an impact on the functions of skeletal muscle [3,4], it is important to define its influencing mechanism. The exploration of microRNAs (miRNAs) will play a positive role in broadening our understanding of controlling factors for skeletal muscle function, and improving the understanding and application of current therapeutic strategies in skeletal muscle diseases [5]. This article summarizes the latest research achievements of microRNAs associated with skeletal muscle function, explores the functions and corresponding regulatory mechanisms of miRNAs in some physiological and pathological conditions, in an attempt to provide the reference for developing novel and effective intervention strategies for maintaining and improving the functions of skeletal muscle
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