Regulatory role of endothelin-1, brain natriuretic peptide and irisin in the development of the immune response to short-term general cooling

Abstract

The paper presents data on the study of the regulatory role of short peptides of endothelin-1, brain natriuretic peptide (Nt-pro-BNP) and irisin in the development of the immune response in humans for short-term cooling. Surveyed 73 people living in the city of Arkhangelsk, 60 of them women and 13 men aged 21 to 50 years. It has been established that the content of Nt-pro-BNP, endothelin-1 and irisin is in a wide range of fluctuations in persons living in the city of Arkhangelsk. As a result of short-term general cooling at - 25 ° C for 5 minutes, three groups of individuals with a change in the content of short peptides can be distinguished: a decrease in the concentration recorded in 24.66% of the examined individuals in reactions with endothelin-1, Nt-pro-BNP and 28.77% with iris, an increase of 21.92-35.61% of individuals and no change in the content — 39.73-49.32% of those examined. Regardless of the concentration of short peptides, 20.54% of the respondents react by reducing the total content of lymphocytes and their activated forms. Improving the efficiency of catecholamine use. Low levels of endothelin-1 and irisin are associated with a high content of natural immunosuppressant IL-10. The decrease in lymphocyte content in response to general cooling occurs against the background of an increase in the pro-inflammatory cytokine TNF-α, the reaction on the part of which is accompanied by low levels of Nt-pro-BNP.