Abstract
Injection of nonradioactive dopa (1 mg/mouse) before injection of [3H]dopa (20 μCi/mouse) into albino mice with Harding-Passy melanoma leads to increased accumulation of tritium in the tumor tissue. Radioactivity of the melanoma in this experimental group was twice as high as the radioactivity of the tumor tissue in animals receiving injections of [3H]dopa alone. Investigation of adenylate cyclase and phosphodiesterase activity and the cyclic AMP level in the melanoma of the mice 2 h after injection of dopa (1 mg/mouse) revealed accumulation of cyclic AMP and increased phosphodiesterase activity; adenylate cyclase activity was depressed. It is suggested that dopa exerts its effect not only as a precursor of melanin, but also through the cyclic AMP system, affecting the activity of enzymes of melanogenesis.
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