Abstract

Primary aldosteronism (PA), one of the most frequent causes of secondary hypertension, is mainly composed of two major subtypes: aldosterone-producing adenoma (APA) and bilateral hyperaldosteronism (BHA)

Highlights

  • Aldosterone-producing adenoma (APA): aldosterone-producing adenoma, AVS: adrenal venous sampling, BHA: bilateral hyperaldosteronism, MC2R: melanocortin 2 receptor, PA: primary aldosteronism, PAC: plasma aldosterone concentration, StAR: steroidogenic acute regulatory protein, zona fasciculata (ZF): zona fasciculate, ZG: zona glomerulosa, Primary aldosteronism (PA) is a pathological condition where aldosterone is over-produced from the adrenal gland either unilaterally or bilaterally, independent of the renin-angiotensin system which in normal condition is in charge of regulating aldosterone production[1]

  • In this Mini-review, we focus on the role of adrenocorticotropic hormone (ACTH) on blood aldosterone level in cases of APA and compare it to that in cases of other forms of PA

  • In 2011, we reported that ACTH stimulation test after dexamethasone administration is a useful procedure to detect APA among those with suspected PA, with a high diagnostic accuracy[21]

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Summary

Introduction

APA: aldosterone-producing adenoma, AVS: adrenal venous sampling, BHA: bilateral hyperaldosteronism, MC2R: melanocortin 2 receptor, PA: primary aldosteronism, PAC: plasma aldosterone concentration, StAR: steroidogenic acute regulatory protein, ZF: zona fasciculate, ZG: zona glomerulosa, Primary aldosteronism (PA) is a pathological condition where aldosterone is over-produced from the adrenal gland either unilaterally or bilaterally, independent of the renin-angiotensin system which in normal condition is in charge of regulating aldosterone production[1]. Differential regulation of blood aldosterone level in APA and BHA The blood aldosterone level is regulated mainly by angiotensin II (AII) and serum potassium level, and, to a lesser extent, by adrenocorticotropic hormone (ACTH)[1].

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