Regulatory RNAs in the molecular pathology of neoplasia

Abstract

<p indent="0mm">Deregulation of gene expression is the fundamental basis of tumorigenesis and tumor progression. Regulatory RNAs play important roles at multiple levels of gene expression regulation and in various cell biological processes. Major progress has been made in molecular biological research of neoplasia regarding biogenesis, biological functions, roles, and molecular mechanisms of various regulatory RNAs, including microRNA, circular RNA, long noncoding RNA, piRNA, snoRNA, and tsRNA. The results of basic research have been gradually translated into clinical applications. Herein, we review the essential progress in the research on regulatory RNAs in the molecular biology of tumors.