Regulatory peculiar features of uncontrolled bronchial asthma

Abstract

Romanchuck O. P., Bazhora Ya. I. Regulatory peculiar features of uncontrolled bronchial asthma. Journal of Education, Health and Sport. 2018;8(1):330-346. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.1405627 http://ojs.ukw.edu.pl/index.php/johs/article/view/5883 The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part B item 1223 (26.01.2017). 1223 Journal of Education, Health and Sport eISSN 2391-8306 7 © The Authors 2018; This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 23.01.2018. Revised: 26.01.2018. Accepted: 31.01.2018. Regulatory peculiar features of uncontrolled bronchial asthma O. P. Romanchuck, Ya. I. Bazhora Odessa National Medical University, Ukraine e-mail:yana19_91@ukr.net Abstract Bronchial asthma (BA) is a multifactorial disease which develops under the influence environmental factors in the presence of individual’s genetic predisposition. The mechanisms associated with the respiratory system dominate in its pathogenesis. The objective: to determine the regulatory features of the uncontrolled course of asthma. The results obtained. At the outpatient stage of treatment 71 male and female patients, mean age 41.0 ± 0.8 have been examined with the use of spiroarteriocardiorhythmography (SACRG). The patients under examination were divided into 2 groups: the group of comparison (n = 20), and the main one (n = 51). Alfa - coefficient in high (BRHF) and low (BRLF) frequencies, hemodynamic and minute volume of blood circulation (HMV, l), indexes of cardiovascular and respiratory systems synchronization and parameters of the cardiovascular system in patients with asthma were determined. Conclusions. In BA at the background of total respiratory capacity significant increase and growth of neurohumoral regulatory influences there is a significant decrease of the sympathetic link activity in the regulation of uncontrolled respiration and relative reduction of the volume velocity of inspiration, which should be taken into account when determining the severity of asthma. Key words: bronchial asthma, neurohumoral regulatory influences, uncontrolled breathing.