Abstract
The death associated protein kinases (DAPKs) are a family of calcium dependent serine/threonine kinases initially identified in the regulation of apoptosis. Previous studies showed that DAPK family members, including DAPK1, DAPK2 and DAPK3 play a crucial regulatory role in malignant tumor development, in terms of cell apoptosis, proliferation, invasion and metastasis. Accumulating evidence has demonstrated that non-coding RNAs, including microRNA (miRNA), long non-coding RNA (lncRNA) and circRNA, are involved in the regulation of gene expression and tumorigenesis. Recent studies indicated that non-coding RNAs participate in the regulation of DAPKs. In this review, we summarized the current knowledge of non-coding RNAs, as well as the potential miRNAs, lncRNAs and circRNAs, that are involved in the regulation of DAPKs.
Highlights
Edited by: Florence Pinet, INSERM U1167 Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement, France
We summarized the current knowledge of non-coding RNAs, as well as the potential miRNAs, long non-coding RNA (lncRNA) and circRNAs, that are involved in the regulation of death associated protein kinases (DAPKs)
We conducted a comprehensive review of studies on non-coding RNAs and DAPKs to understand the current research status, and to explore the potential regulatory miRNAs, lncRNAs and circRNAs for the expression of DAPKs
Summary
DAPK2 is mainly expressed in the hematopoietic compartment. At present, DAPK2 has been found to act as a tumor suppressor in several types of leukemia (Rizzi et al, 2007; Humbert et al, 2014; Ye et al, 2016). MiR-34 was down-regulated in prostate cancer, breast cancer, lung cancer and osteosarcoma compared with normal tissues, but was up-regulated in liver cancer (Zhang et al, 2019a) These studies suggested that same gene may have a completely different expression pattern in different types of tumors due to the regulation of miRNA. Further study revealed that circSLC8A1 acts as a miRNA sponge for miR-494 and miR-130b, and subsequently regulate the expression of their target gene PTEN (gene of phosphate and tension homology deleted on chromsome ten), thereby suppressed the progression of bladder cancer (Lu et al, 2019). Higher level of miR-191 in ovarian cancer patient samples compared with controls was verified, and miR-191 was confirmed to directly target DAPK1 and regulate its expression using luciferase assay. In ischemic stroke, increased lncRNA AK038897 and decreased miR-26a-5p levels were observed in mouse brains following middle cerebral
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