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Abstract
Human polymorphonuclear leukocytes release superoxide not only during phagocytosis but also on contact with various surface active agents including chemotactic peptides, calcium ionophore A23187 and phorbol myristate acetate. Superoxide production induced by these soluble stimuli is modulated by potent inactivators of serine proteases, cyclic AMP and cytoskeleton-affecting agents, although the effects of these pharmacologic agents are different according to the stimuli used, suggesting that chemotactic peptides, ionophore A23187 and phorbol myristate acetate may activate the oxidative metabolism of human polymorphonuclear leukocytes through different mechanisms. It is the purpose of this article to review the recent advances in the regulatory mechanisms of superoxide production in human polymorphonuclear leukocytes.
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