Abstract
A present review is devoted to the analysis of literature data and results of our own research in the field of the Na,K-ATPase molecular diversity. Abundant evidence shows that the Na,K-ATPase alpha2 isoform is not only involved in various specific cell functions but also affected by different regulatory factors as compared to the alpha1 isoform which carries the main pump function. Data gathered suggest that these features of alpha2 isoform are determined by its functional and molecular environment, localization in specific cellular microdomains and also by less stable integration into the cell membrane as compared to other isoforms of the Na,K-ATPase alpha subunit.
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