Abstract
The BMP pathway positively regulates murine brown adipogenesis. We herein examined the mRNA levels of BMPs and activin βB as well as receptors for the BMP pathway in the adipose tissues of cattle fed diets with a differential ratio of concentrate to roughage or a vitamin A-deficient diet. The expression of activin βB was significantly increased in the subcutaneous fat depot of animals fed the concentrate diet, while the vitamin A-deficient diet significantly increased the expression of BMP4 in the mesenteric fat depot. The expression of receptors for the BMP pathway, ALK2, ALK3, ActRIIA, and BMPR2, showed a similar pattern to that of BMP4 and activin βB in response to the dietary treatments. The results of the present study demonstrated that diet modulated the expression of components of the BMP pathway and may be responsible for the regulatory expression of brown/beige adipocyte-related genes in the adipose tissues of cattle.
Submitted Version (
Free)
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
