Regulatory Effects of Skate Skin-Derived Collagen Peptides with Different Molecular Weights on Lipid Metabolism in the Liver and Adipose Tissue.

Minji Woo,Jeong Sook Noh

doi:10.3390/biomedicines8070187

Minji Woo, Jeong Sook Noh

Open Access

https://doi.org/10.3390/biomedicines8070187

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Abstract

This study investigated the effects of skate skin collagen peptide (SSCP) with different molecular weights (MWs) on the lipid metabolism in the liver and adipose tissue. Male db/db mice were orally administered with water (control group) or low SSCP (LCP group) or high SSCP (HCP group) MW for 8 weeks whereas male m/m mice were used for comparison (normal group) (n = 10 each group). Compared to the control group, the LCP and HCP groups had lower adipose tissue mass, plasma and hepatic lipid concentrations, and plasma leptin levels (p < 0.05). Protein expression levels of lipogenesis-related protein were reduced in both liver and adipose tissues of SSCP-fed groups whereas those for lipolysis were elevated (p < 0.05). In particular, the LCP had the higher effects relative to the HCP. The above results were supported by histological analysis, revealing that SSCP administration decreased the size of adipose droplets and suppressed hepatic lipid accumulation. Our results showed that SSCP has potential antiobesity properties through the improvement of lipid metabolism in the liver and adipose tissue; in particular, the lower MW of collagen peptide had the greater effects.

Highlights

During the processing of fish, byproducts are generated from the skin, bones, fins, heads, and scales, in which the collagen-containing materials account for up to 30% of the total byproducts [1].Collagen is a major component of animal-derived proteins, and has a wide range of applications, including the cosmetic, pharmaceutical, and food industries, due to its numerous beneficial effects, including antioxidative, lipid lowering, and so on [1,2,3,4,5,6]
Consistent with previous findings, our results showed that the lower collagen peptide molecular weights (MWs) had a larger effect on the improvement of lipid metabolism in the liver and adipose tissue
To identify the potential antiobesity properties of collagen peptide, we report here that skate skin collagen peptide improved lipid metabolism in the liver and adipose tissue

Summary

Introduction

Collagen is a major component of animal-derived proteins, and has a wide range of applications, including the cosmetic, pharmaceutical, and food industries, due to its numerous beneficial effects, including antioxidative, lipid lowering, and so on [1,2,3,4,5,6]. A series of studies have verified the beneficial antioxidative effects of marine collagen peptides [2,3], the improvement of glucose/lipid metabolism [2,4,5], and the facilitation of learning and memory function [6]. The effect of different MWs of skate skin collagen peptide on lipid metabolism and the related mechanisms of action have not been elucidated

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