Abstract
Autophagy is an important process in endogenous substrate degradation by lysosomes within cells, with a degree of evolutionary conservation. Like apoptosis and cell senescence, cell autophagy is a very important biological phenomenon involving the development and growth of biological processes. Abnormal autophagy may lead to tumorigenesis. In recent years, increasing studies have demonstrated that long non-coding RNAs (lncRNAs) and miRNAs can regulate cell autophagy by modulating targetting gene expression. In this review, we will provide an overview of lncRNAs and miRNAs in autophagy modulation and new insights into the underlying mechanisms, as well as their potential utilization in disease diagnosis, prognosis, and therapy.
Highlights
Autophagy is a process of sustaining metabolism and homeostasis by capturing and degrading intracellular components such as proteins and organelles
With the development of gene editing technology, especially the emergence of clustered regularly interspaced short palindromic repeats (CRISPR)/ RISPR associated (Cas), it is expected that more non-coding RNA (ncRNA) will be used as targets for clinical treatment
More autophagy-related long non-coding RNA (lncRNA) and miRNAs have been discovered, most of these studies mainly focussed on their expression and function
Summary
Autophagy is a process of sustaining metabolism and homeostasis by capturing and degrading intracellular components such as proteins and organelles. MTOR DEDD/p62 Sirt1 Beclin1/Vps34/LC3II AMPK/ mTOR ATG5/PI3K/Beclin1 ATG3/ATG7 ULK1 p53 AKT TNBC Bladder cancer Uterine sarcoma CML Lung cancer Colon cancer HCC NSCLC Bladder cancer Glioblastoma medical research with clinical treatment, namely translational medicine, is the focus and difficulty in current scientific research.
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