Abstract
Aim We dynamically observed the expression of CD152 and PD-1 on T-cell surfaces in peripheral blood of liver allorecipients to explore the regulatory effect of FK506 on negative costimulatory molecules. Methods We evaluated 20 liver allorecipients, 19 end-stage liver disease patients, and 20 healthy volunteers for FK506 concentrations measured by an enzyme-multiplied immunoassay technique and flow cytometry to determine T-cell subsets as well as CD152 and PD-1 expression. Results After liver transplantation, the frequency of CD4 + T cells gradually decreased to significantly lower level than those in the disease controls ( P < .05). CD8 + T cells in each treatment group were obviously higher than those in the disease controls ( P < .05). The expression of CD152 on CD4 + and CD8 + T cells was greater than those in healthy controls ( P < .05); and at 2 and 4 weeks, higher than those in disease controls ( P < .05). The expression of PD-1 on CD4 + T cells from the 2 weeks after treatment was significantly greater than that in healthy controls ( P < .05), and that on CD8 + T cells increased obviously from the 4 weeks compared with disease controls ( P < .05). Conclusion FK506 up-regulated the expression of CD152 and PD-1 on the T-cell surface inhibiting proliferation and activation of effector T cells, favoring the survival of allorecipients.
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