Abstract
that CM/IFA-injected animals grafted with MHC class II KO hearts experienced significant prolongation of heart survival as compared to untreated mice (11 1 d vs 24 2 d). We conclude that modulation of CM response can on its own achieve graft prolongation when CD4 alloresponse is oligoclonal, i.e. mediated via indirect allorecognition. Our findings have important implications for the design of future therapies in heart transplantation.
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