Abstract
Regulatory B cells (Bregs) have been shown to play a role in the suppression of a wide variety of immune responses. For the study of autoimmune inflammation, experimental models of arthritis have acted as a valuable tool in understanding the function of Bregs in maintaining immune homeostasis. In this chapter, we will focus on the study of transitional-2 marginal zone precursor Bregs (T2-MZPs) in the context of two experimental arthritis models: antigen-induced arthritis (AIA) and collagen-induced arthritis (CIA). We will specifically focus on how to induce arthritis as well as methods for the isolation and functional study of Bregs both in vitro and in vivo.
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