RegulatorDB: a resource for the analysis of yeast transcriptional regulation.

Abstract

Mutant expression profiles have been published for nearly all the nonessential regulators in yeast, yet there is a need for improved analysis and visualization tools to analyze these data and integrate it with complementary protein-DNA binding data. The RegulatorDB database contains mutant expression profiles and DNA binding data for more than 900 and 250 yeast regulators, respectively. RegulatorDB provides web-based tools to visualize the effects of each mutant regulator on the expression of individual genes or user-selected gene sets, and identify regulators whose targets are enriched in user-selected gene sets. The database can be queried to search for targets of single or multiple regulators. Regulatory networks can be constructed and visualized that include multiple classes of regulators and multiple regulatory layers, including regulator DNA binding data. In summary, RegulatorDB is a powerful resource for the study of yeast gene regulation, from the level of individual genes up to genome-scale networks. Database URL: http://wyrickbioinfo2.smb.wsu.edu/RegulatorDB