Abstract
Wnt signal transduction pathways play crucial roles in animal development, and after birth, they are involved in maintaining cellular and tissue homeostasis. Deregulation of the Wnt-mediated pathways occurs in many human diseases, including a wide range of human cancers. Many years ago, due to the topological similarity between Frizzled receptors and G-protein-coupled receptors, it was proposed that heterotrimeric G-proteins might be involved in the regulation of Wnt/Frizzled-mediated signaling pathways. Currently, there is a wealth of evidence indicating that heterotrimeric G-proteins regulate both canonical and non-canonical Wnt signaling pathways. This review article will discuss some of this evidence and the significance of this interaction.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
