Regulation of Volume-Modulating Ion Transport Systems by Growth Promoters

Abstract

Exposure of quiescent cells to a variety of growth factors and pharmacological mitogens leads to a cascade of biochemical events and ionic changes that occur within minutes and are believed to play crucial roles in the initiation of cell proliferation. The biochemical events induced by growth promoters include increased turnover of inositol phospholipids, protein phosphorylation and increased transcription of several protooncogenes. Modification of monovalent ion (e.g. Na+ and K+) fluxes across the plasma membrane is one of the earliest changes observed in response to growth carriermediated pathways. One of these pathways is the amiloride-sensitive Na+/H+ antiport.KeywordsGrowth PromoterPhorbol EsterOkadaic AcidCotransport ActivityCotransport SystemThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.