Abstract
RGK proteins belong to the Ras superfamily of monomeric G-proteins, and currently include four members — Rad, Rem, Rem2, and Gem/Kir. RGK proteins are broadly expressed, and are the most potent known intracellular inhibitors of high-voltage-activated Ca2+ (CaV1 and CaV2) channels. Here, we review and discuss the evidence in the literature regarding the functional mechanisms, structural determinants, physiological role, and potential practical applications of RGK-mediated inhibition of CaV1/CaV2 channels. This article is part of a Special Issue entitled: Calcium channels.
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