Abstract

Development of a vertebrate organism entails a complex network of inductive interactions whereby cell fate is progressively specified according to a genetically determined body plan. In order to achieve development of the right structure in the right place of the embryo, positional information has to be given to individual cells throughout morphogenesis to interact with, or become part of, the gene activation program, eventually leading to the terminally differentiated state. How positional information is encoded in embryos and decoded by each cell at any given time during development is largely unknown at both cellular and molecular levels.

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