Abstract
Research on the POU proteins has focused on their regulatory roles during development and the dissection of their functional domains to establish how they bind particular DNA sequences and activate transcription of distinct sets of genes. The pituitary-specific transcription factor Pit-1/GHF-1, the ubiquitous transcription factor Oct-1 and the predominantly B cell transcription factor 0ct-2 have been the major subjects of biochemical dissection, while the developmental roles of Pit-1/GHF-1 and the Caenorhabditis elegans cell lineage control gene unc-86 have been established by a combination of expression studies and genetic analysis. A minireview.
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