Regulation of TLR4 signaling through the TRAF6/sNASP axis by reversible phosphorylation mediated by CK2 and PP4

Abstract

SignificanceTNF receptor–associated factor 6 (TRAF6) is a key signaling molecule in innate immune response. Here, we identify a previously unrecognized role of protein phosphatase 4 in the regulation of TRAF6 activation through dephosphorylation of a native TRAF6 inhibitor, somatic nuclear autoantigenic sperm protein, to resolve the inflammatory response initiated by Toll-like receptor 4.