Abstract
Previous studies have shown that rats bearing transplantable Walker 256 carcinoma in the thigh have decreased serum total and free T4 and T3 concentrations as well as a decrease in the concentration of hepatic nuclear T3 receptors. Despite these findings, the tumor-bearing (T) rats appeared euthyroid, since the serum TSH concentration remained unchanged, and the induction of the thyroid hormone-sensitive hepatic enzymes a-glycerophosphate dehydrogenase and malic enzyme appeared normal. To evaluate the mechanisms whereby serum TSH was maintained in the normal range in T rats in association with decreased serum T4 and T3 concentrations, we studied the regulation of TSH secretion in groups of control (C) and T rats. The pituitary TSH contents were similar in the two groups of animals, and an iv injection of TRH (5 μg/100 g BW) resulted in a 10-fold increase in plasma TSH concentrations in the control group 15 min after injection. The TSH concentrations achieved after TRH injection were significantly greater ...
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