Abstract
Objective/purpose TSLP plays a major role in the induction and effector phases of allergic diseases by acting on dendritic cells, mast cells (MCs), T cells and CD34 hemopoietic progenitor cells. Whereas the cellular origin and the mechanisms regulating TSLP production are well documented, little is known about the regulation of TSLP receptor expression. We analyzed the regulation of TSLP-R with several cytokines, TLR ligands and drugs commonly used to treat asthma.
Highlights
From AllerGen NCE Inc.’s Fifth Annual Research Conference: Innovation from Cell to Society Québec City, QC, Canada. 7-9 February 2010
Neonatal CD34+ cells were examined by two-colour analysis for the expression of CD34 and Thymic Stromal Lymphopoietin (TSLP)-R after 48 hours of incubation with or without: 1) cytokines (IL-1, TNF, IL-4, IFN-g, TGF-b) used alone or in combination; 2)inflammatory mediators (PGE2, LTC4 and PGD2); 3) bacterial products (SAC, LPS and PGN); 4) TLR ligands (TLR3, TLR5, and TLR7); 5) dexamethasone and isoproterenol
Expression of TSLP-R on CD34+ cells was markedly enhanced by IL-1/TNF; this effect was suppressed by IL-4, IFN-g and TGF-b and augmented by PGE2
Summary
From AllerGen NCE Inc.’s Fifth Annual Research Conference: Innovation from Cell to Society Québec City, QC, Canada. 7-9 February 2010. Regulation of Thymic Stromal Lymphopoietin (TSLP) receptor expression From AllerGen NCE Inc.’s Fifth Annual Research Conference: Innovation from Cell to Society Québec City, QC, Canada. Objective/purpose TSLP plays a major role in the induction and effector phases of allergic diseases by acting on dendritic cells, mast cells (MCs), T cells and CD34+ hemopoietic progenitor cells.
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