Abstract
Pathogenic Neisseria meningitidis , a causal agent of bacterial meningitis, secretes capsular polysaccharides of different compositions that differentiate the serogroups. Since the capsule is an important virulence factor that determines adhesion to epithelia and ability to invade tissues, there is need to understand the underlying mechanisms for its expression. Furthermore, bacterial polysaccharides are potential sources of novel biomaterials. The expression of the capsule production genes is regulated, and this study reveals a mechanism involving a transcription factor, HTH_XRE, whose function in Neisseria meningitidis is not known. It extends the understanding of capsular expression regulation by identifying other control elements in the promoter region. The results will have applications in optimizing biomaterial production or in developing therapeutic interventions.
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