Abstract
Pretreatment of mice with a suboptimal immunizing dose of SRBC (10 6) prepares the animals to make an “accelerated” response to an optimal immunizing dose of SRBC (10 8) given two or more days later. The “accelerated” response is characterized by a shift to the left of the kinetic curves when the number of antibody forming cells are plotted against time. The response to the 10 8 SRBC thus reaches a peak earlier in the pretreated animals than in the nonpretreated controls. The slopes of the kinetic curves are parallel and the magnitude of the response is not significantly different in pretreated and nonpretreated groups. Multiple injections of 10 6 SRBC give a greater “accelerated” response but one injection with the total dose of the multiple injections results in kinetics similar to those obtained with the single 10 6 dose. The response is antigen specific. It is suggested that the basis of the “accelerated” response is proliferation of a cellular component(s) without differentiation into an antibody forming cell.
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