Regulation of the IgE response by IgE class-specific suppressor T hybridomas.

Abstract

Previous studies have demonstrated the presence of IgE class-specific helper and suppressor T cells which show a regulatory effect only on the IgE antibody response (1,2,3). Thus, T cells from mice primed with hapten (DNP or PC)2)-coupled mycobacterium showed the selective suppressive effect on the in vivo as well as in vitro IgE responses against DNP-antigen or PC-antigen, respectively (2,4,5). The suppressor function was shown to be mediated by antigen-nonspecific, IgE class-specific suppressor factor(s) (IgE-TsF) released from DNP- or PC- mycobacterium (Myc)-primed T cells by antigen-specific stimulation. IgE-TsF had neither Ig determinants nor antigen binding sites (4), but bore the I region gene products (6). Furthermore, IgE-TsF has been proved to have the binding site(s) for IgE molecules as well as I region gene products on the same molecules (7). In the present experiment, we have established IgE class-specific suppressor T hybridomas and studied the function and properties of IgE specific suppressor factors obtained from them.KeywordsSuppressor ActivityHybrid CloneSuppressor FactorSpecific SuppressorRegion Gene ProductThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.