Abstract
Introduction: Cholangiocarcinoma (CCA) is characterized by high resistance to chemotherapy and poor prognosis. Epidermal growth factor (EGF) is involved in CCA development, and overexpression of the EGF receptor (EGFR) has been linked to tumor progression. The EGF signaling pathway may be associated with activation of extracellular signal-regulated kinase 5 (ERK5), a protein belonging to the MAPK family involved in the pathogenesis of different types of cancer. Additionally, ERK5 is implicated in cytoskeletal remodeling and cell motility. The purpose of this study was to investigate the role of ERK5 in the biology of CCA cells.
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