Regulation of the Basolateral Na+, K+-ATPase in the Activation of Electrogenic Na+Absorption Induced by Isoproterenol in the Rat Distal Colon

Abstract

We investigated the effects of cAMP on the basolateral Na(+), K(+)-ATPase and apical amiloride-sensitive Na(+) channel in the rat distal colon. Under mucosal treatment with nystatin, isoproterenol and forskolin increased the basolateral Na(+) pump current. Under serosal treatment with ouabain, both agents slightly increased the amiloride-sensitive Na current, but not to a significant level. We concluded that cAMP activates the basolateral Na(+), K(+)-ATPase in the rat distal colon.