Abstract
Lactate-grown cultures of Acinetobacter sp. strain 3B-1 synthesize constitutively all enzymes except the 4-hydroxyphenylacetic acid-3-hydroxylase. All enzymes are further synthesized when strain 3B-1 is grown with 4-hydroxyphenylacetic acid. Induction studies with two mutant strains, one defective in the 3-hydroxylase, and the other defective in the dehydrogenase, indicate that 4-hydroxyphenylacetic acid induces the 3-hydroxylase only, and the second metabolite 3,4-dihydroxyphenylacetic acid appears to induce 3,4-dihydroxyphenylacetic acid-2,3-dioxygenase and subsequent enzymes. Thus, the enzymes of the 4-hydroxyphenylacetic acid meta -cleavage pathway are synthesized following at least two sequential inductive events.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
