Abstract
To investigate the regulation of β 2AR expression in rat ventral prostate the effects of castration and testosterone replacement on the β 2AR were studied by ligand binding and Northern blot analysis. Orchidectomy depressed β 2AR number by 50% within 4 days and testosterone administration to 4-day castrates produced a rapid and complete recovery of β 2AR number within 24 h. In contrast to receptor number, β 2AR mRNA levels did not change relative to total RNA following castration. However, during the testosterone replacement period β 2AR mRNA levels rose transiently, reaching a maximum (3.5-fold) between 8 and 12 h, and this increase in mRNA preceded the recovery in β 2AR number in the membrane. Regulation of β 2AR gene expression by testosterone in the ventral prostate is thus complex and probably involves both transcriptional and post-transcriptional components.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
