Abstract
Taurine is actively transported into the renal tubular cell by a Na+ — and Cl−-dependent system specific for this β-amino acid and structural analogs (14). The proximal epithelial transport system regulates the urinary excretion of taurine. Taurine transport is regulated by the dietary intake of taurine in the rat (1), by extracellular taurine concentration in kidney cells in culture (7), and by medium osmolality in MDCK cells (11). We have previously demonstrated that taurine transport in both MDCK and LLC-PK1 cells is increased following incubation of cell monolayers in taurine-free medium and in decreased following incubation of cells in high extracellular taurine (8). The LLC-PK1 is a porcine cell line of proximal tubular origin and the MDCK (Madin Darby Canine Kidney) cell line is from the collecting duct of the dog.
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