Abstract
Central serotonin (5-HT) is an anorexigenic neurotransmitter in the brain. However, accumulating evidence suggests peripheral 5-HT may affect organismal energy homeostasis. Here we show 5-HT regulates white and brown adipose tissue function. Pharmacological inhibition of 5-HT synthesis leads to inhibition of lipogenesis in epididymal white adipose tissue (WAT), induction of browning in inguinal WAT and activation of adaptive thermogenesis in brown adipose tissue (BAT). Mice with inducible Tph1 KO in adipose tissues exhibit a similar phenotype as mice in which 5-HT synthesis is inhibited pharmacologically, suggesting 5-HT has localized effects on adipose tissues. In addition, Htr3a KO mice exhibit increased energy expenditure and reduced weight gain when fed a high-fat diet. Treatment with an Htr2a antagonist reduces lipid accumulation in 3T3-L1 adipocytes. These data suggest important roles for adipocyte-derived 5-HT in controlling energy homeostasis.
Highlights
Central serotonin (5-HT) is an anorexigenic neurotransmitter in the brain
5-Hydroxytryptamine (5-HT, serotonin) is a monoamine that modulates central and peripheral functions. It is primarily found in the gastrointestinal tract, platelets, pineal gland and the central nervous system. 5-HT is synthesized from the essential amino acid tryptophan by the sequential actions of tryptophan hydroxylase (Tph) and aromatic amino acid decarboxylase
To know the localized actions of HT receptor (Htr)[3] in brown adipose tissue (BAT), we explored the effects of an Htr[3] antagonist on immortalized brown adipocytes (IBA)
Summary
Central serotonin (5-HT) is an anorexigenic neurotransmitter in the brain. accumulating evidence suggests peripheral 5-HT may affect organismal energy homeostasis. Mice with inducible Tph[1] KO in adipose tissues exhibit a similar phenotype as mice in which 5-HT synthesis is inhibited pharmacologically, suggesting 5-HT has localized effects on adipose tissues. 5-Hydroxytryptamine (5-HT, serotonin) is a monoamine that modulates central and peripheral functions It is primarily found in the gastrointestinal tract, platelets, pineal gland and the central nervous system. The enhancement of 5HT activity using a selective SERT inhibitor was associated with weight loss, but the effect was transient and restoration occurred during maintenance period[12]. These discordant results suggest that peripheral 5-HT might have opposite functions to central 5HT in the regulation of energy homeostasis
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
