Abstract
In the present report we analyzed the long-term effects of neonatal noradrenergic denervation on the regulation of paradoxical sleep in the rat. The locus coeruleus was destroyed bilaterally at 4 days of age by direct infusion of 6-hydroxydopamine into the nuclei. After they reached adulthood, the rats received either i.p. injections of a β-blocker, propranolol, or the same treatment combined with intraventricular infusion of a β-agonist, isoproterenol. Several doses of each drug were tested. The effects of propranolol, alone and together with isoproterenol, on paradoxical sleep (a decrease for the former drug and a restoration for the latter combination) were significantly more pronounced in the lesioned group than in age-paired controls. These data illustrate a functional aspect of the denervation supersensitivity phenomenon in β-receptors.
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