Abstract
Congenital heart disease is the most common birth defect in China, of which heart valve dysplasia is an important phenotype.Heart valve development is an important process of embryonic development, which is regulated by a variety of signaling pathways.If the process of proliferation, differentiation or migration of endothelial cells and cardiomyocytes is abnormal, the heart valve will develop abnormally and the valvular heart disease may occur.Tissue explant systems and various animal model experiments have demonstrated that multiple signaling pathways interact to form a vast regulatory network that collectively regulates the development of heart valves.This review will highlight the nost intensively studied signaling pathways in epithelial-mesenchymal transition, including VEGF, NFATc1, Notch, Wnt, TGF-β, ErbB, and NF1 signaling pathways. Key words: Cardiac valve; VEGF; NFATc1; Notch; Wnt; TGF-β; BMP; ErbB; NF1
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