Regulation of Provwx Transcription By Local Chromatin Remodelling

Abstract

Nucleoid Associated Proteins (NAPs) are architectural proteins that bind along the bacterial chromosome driving its compaction and organisation. They do so by lateral filament formation along the DNA, DNA bending, or DNA bridging, the latter of which results in the formation of long- and short-range DNA loops that determine the global and local structural organisation of the chromosome. NAP binding is sensitive to environmental changes such as fluctuations in temperature, pH, and osmolarity. Hence, NAPs organise the bacterial chromosome into a dynamic structure that is remodelled in response to changes in the cell environment.