Abstract
The posterior lateral hypothalamus (PLH) is a brain region involved in cortical activation and maintenance of behavioral arousal. Spontaneous and evoked neuronal activities were recorded in the PLH of cats before and during local warming of the preoptic-anterior hypothalamus (POAH). Forty-six percent of PLH neurons recorded in awake cats decreased spontaneous discharge during POAH warming. In the absence of POAH warming, these same cells exhibited significantly lower discharge rates in non-rapid eye movement (NREM) sleep compared to waking. Responses of PLH neurons to POAH warming were also investigated in sleeping cats to determine whether hypothalamic thermosensitive neurons modulated sleep-wake regulation across arousal states. POAH warming had no influence on spontaneous activities of PLH neurons during NREM sleep, but suppressed activity of a small subset of neurons during rapid eye movement (REM) sleep. Thus, during wakefulness or REM sleep, hypothalamic thermosensitive neurons may modulate behavioral state via inhibition or disfacilitation of arousal systems.
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
