Abstract
A trial natriuretic peptide (ANP) is released from cardiac atria into circulation and induces diuresis and natriuresis. We studied plasma ANP in children using a sensitive radioimmunoassay. In 80 normal children aged 4 weeks to 16 years ANP averaged 27.8±14.0 fmol/ml (x̄±SD). Neonates had only slightly higher mean ANP levels, whereas in premature infants at day 1 of life ANP was up to 10 times higher than in normal children (252.6±210.0 fmol/ml, n:11). The increase in plasma volume Tnduoed by albumin infusion in children with nephrotic syndrome (n:9) caused a rise in plasma ANP from 36.1±22.6 to 151.4 ± 52.0 fmol/ml. ANP correlated with urine flow (r:0.64, p<0.01) and with sodium excretion (r:0.62, p<0.01). Reduction of volume overload by hemodialysis in children with chronic renal failure (n:14) resulted in a fall of elevated plasma ANP from 87.1±39.4 to 42.8± 26.0 fmol/ml (p < 0.001). This decrease correlated with concomitant reduction of body weight. These observations suggest that volume expansion is a potent stimulus of ANP release in children and that this hormone is important in volume homeostasis. Supported by Deutsche Forschungsgemeinschaft Ra 326/1-2
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