Abstract
Cells cultured from human tumors of neural origin offer an easily accessible avenue to the study of the neurotropism of OC43 virus in human cells. Using a tissue culture adapted strain of OC43 virus a comparative study of the replication and persistence of OC43 virus in two cell lines was undertaken. U87-MG cells of glioblastoma origin which were relatively insusceptible to infection (yield at 24 hrs = 1 pfu per cell) and RD cells of rhabdomyosarcoma origin which were susceptible to infection (yield at 24 hrs = 30 pfu per cell) were studied. The purpose of this study was to establish persistent infections in these cells, observe how virus replication is regulated and to cure the cells of the infection.
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