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Abstract
Anti-tumor specific immune responses are modulated during tumor development via different escape mechanisms abrogating the process of effective immunological tumor destruction. In this study we analyzed the p53 specific immune response in colorectal cancer patients (n = 24) depending on their UICC stage and characterized their regulatory T cell functions independent of the p53 mutational status.
Highlights
Anti-tumor specific immune responses are modulated during tumor development via different escape mechanisms abrogating the process of effective immunological tumor destruction
T cells from patients in UICC III (n = 7) and IV (n = 7) expressed higher IL-10 levels in response to p53 peptide than patients in UICC I and II (n = 6) (26 and 62 spots/105 cells versus 14 spots/105 cells, respectively), indicating that the UICC stage may play a crucial role in IL-10 production in response to p53 peptides
Other p53 peptides led to IFN-γ production but no correlation was observed between the UICC stage and the Th1 response
Summary
Anti-tumor specific immune responses are modulated during tumor development via different escape mechanisms abrogating the process of effective immunological tumor destruction. Regulation of p53 tumor specific immune responses in colorectal cancer patients Email: AM Waaga-Gasser* - waaga-gasser@chirurgie.uni-wuerzburg.de * Corresponding author from Association for Immunotherapy of Cancer: Cancer Immunotherapy – 2nd Annual Meeting Mainz, Germany, 6–7 May 2004
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