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Abstract
Previous studies have demonstrated that gonadotropin increases ornithine decarboxylase (ODC) activity in the rat ovary. The increase of ODC activity following gonadotropin stimulation is localized primarily to proliferating granulosa cells. The present studies were undertaken to characterize the mechanism of this hormone-induced increase of ODC. A single intraperitoneal injection of PMSG resulted in a 15-fold increase in ODC activity ( p < 0.0001). Activity was maximal 1 day following PMSG administration, and thereafter declined with time. PMSG also induced an increase in ODC mRNA levels ( p < 0.0001). However, ODC mRNA increased only 2-fold, as compared with a 15-fold increase in ODC activity. Actin mRNA levels were unaffected by PMSG. These results demonstrate that PMSG-induced increase in ODC activity cannot be fully explained by an increase in ODC mRNA, thus indicating that part of the regulation of ODC by PMSG is occurring at the translational and/or posttranslational level. Such regulation is likely a necessary dimension of the fine control of the levels/activity of this important enzyme which has a very short half-life.
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