Abstract
Orai1 and STIM1 are essential for store operated calcium entry (SOCE) in T cells, and mutations in either protein cause primary immunodeficiency disease. Orai1 is a plasma membrane localized calcium channel, while STIM1 is localized to the endoplasmic reticulum (ER) where it senses ER calcium store content. Upon depletion of the ER calcium store, Orai1 and STIM1 assemble at ER-plasma membrane junctions to form an activated calcium channel, allowing for SOCE. How Orai1 and STIM1 assemble after store depletion is incompletely understood.
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