Abstract
Previous research has led to the discovery that the plasma membrane signaling protein PLCβ1 is sometimes present in the nucleus. Little is known how PLCβ1 is regulated in the nucleus on the plasma membrane. PLCβ1 activity is regulated by G proteins but these have not been found in the nucleus. The focus of this study is to find binding partners for nuclear PLCβ1 and investigate their role in the regulation of its activity in the nucleus. A protein called translin-associated factor-X, TRAX, has been identified as a potential binding partner for nuclear PLCβ1. The work done in this report shows that the two proteins bind in vitro and in living cells. Using a combination of biophysical and biochemical methods, we find the two proteins interact and that TRAX may regulate nuclear PLCβ1 activity.
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