Abstract
To clarify the mechanism of regulation in nuclear DNA synthesis, the DNA synthesis of isolated nuclei was examined. The incorporation of 3HTTP into DNA by the nuclei isolated from normal rat liver by isotonic sucrose solution was not detectable, but could be activated to the same level as that in regenerating liver by further purification using hypertonic sucrose procedure. Therefore the nuclear DNA synthesis in normal rat liver was considered to be repressed in a masked state, which was not accounted for by the degradation of substrates during incubation.
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