Abstract

The activity of nitric oxide synthases (NOS) is dynamically regulated by calcium-calmodulin, and further modulated by a wide range of differentially-targeted reversibly oxidized protein kinases and phosphoprotein phosphatases. This presentation will review the roles of intracellular oxidants in the regulation of NOS activity in vascular endothelial cells and cardiac myocytes and will present the results of recent studies using informative hydrogen peroxide biosensors and novel chemogenetic approaches.

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