Abstract
In addition to the selective ion channels such as voltage-gated K+ (KV), Na+ (NaV) and Ca2+ (CaV) channels, neurons also express a voltage-independent, non-selective cation channel NALCN. NALCN contributes to the TTX- and Cs+ -resistant Na+ leak conductance in neurons and is activated by neuropetides substance P and neurotensin via a G-protein independent pathway that requires the Src family of tyrosine kinases. The pore-forming subunit of NALCN resembles that of the 24 transmembrane spanning (24TM) CaVs and NaVs, but lacks some of the charged residues in the S4s and has a unique sequence signature in the selectivity filter region.
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