Abstract
The kinetic properties of the Na+/H+ antiporter, present in the brush border membrane of the renal proximal tubule, have been delineated in a series of studies on isolated brush border membrane vesicles (1,2). In order to determine the factors which regulate this transport system using this approach, the system has had to be perturbed either in vivo or in vitro prior to fragmenting the cell for preparation of isolated vesicles. Whether disruption of the cell alters the apparent response to exogenous stimuli; e.g. hormones, neurogenic influences, etc., is not clear.
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