Abstract
SPECIFIC AIMThe purpose of the present study was to test the hypothesis that the catabolic state induced by burn injury, sepsis, or endotoxemia is associated with an increase in muscle myostatin mRNA content and a concomitant reduction in muscle IGF-I or IGF-II mRNA. The role of endogenous glucocorticoids and tumor necrosis factor α (TNF-α) in mediating the burn-induced changes in myostatin mRNA was also assessed by treating rats with selective antagonists to these catabolic factors.PRINCIPAL FINDINGS1. Effect of burn, endotoxin, or sepsis on myostatin mRNAA full-thickness scald injury covering ∼30% of the total body surface area was produced in male rats. Twenty-four hours after thermal injury, Northern blot analysis indicated that steady-state myostatin mRNA levels were increased more than threefold in the gastrocnemius (C=1.0±0.2 AU vs. B=3.3±0.4 AU; P < 0.05). In contrast, the injection of Escherichia coli endotoxin (100 μg/100 g BW) or the induction of a polymicrobial sepsis did not significantly alt...
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