Abstract
miR-30b, which is encoded by the gene located on chromosome 8q24.22, plays an important role in a variety of diseases. In most types of tumors, miR-30b significantly inhibits the proliferation, migration, and invasion of cancer cells through the regulation of target genes. Moreover, miR-30b can inhibit the PI3K/AKT signaling pathway through the regulation of EGFR, AKT, Derlin-1, GNA13, SIX1, and other target genes, thus inhibiting the EMT process of tumor cells and promoting apoptosis. In addition, miR-30 plays a significant role in alleviating drug resistance in tumor cells. Although the use of miR-30b as a clinical diagnostic indicator or anticancer drug is still facing great difficulties in the short term, with the deepening of research, the potential application of miR-30b is emerging.
Highlights
1 Introduction miRNA is a group of noncoding short sequence singlestranded RNAs that attenuate or eliminate the function of downstream genes by targeting the 3′-untranslated region (3′-UTR) structure of mRNA and indirectly regulate physiological and pathological states [1]
Even a single miRNA is involved in a wide range of functional and metabolic pathways, which can directly or indirectly affect the expression of multiple downstream target genes and their corresponding biological functions
Since the targets of miR-30b contain numerous proteins related to proliferation, migration, and invasion, the dysregulation of miR-30b expression leads to the uncontrolled development of tumor cells (Table 1)
Summary
MiRNA is a group of noncoding short sequence singlestranded RNAs (ssRNAs) that attenuate or eliminate the function of downstream genes by targeting the 3′-untranslated region (3′-UTR) structure of mRNA and indirectly regulate physiological and pathological states [1]. A large number of studies have shown that miRNAs play a key role in many regulatory pathways such as body development, cell differentiation, cell apoptosis, metabolism, and signal transduction [10,11]. Even a single miRNA is involved in a wide range of functional and metabolic pathways, which can directly or indirectly affect the expression of multiple downstream target genes and their corresponding biological functions. Previous studies have found that more than half of nematode miRNAs have sequence homology with human-expressed miRNAs [16]. These studies indicate that miRNAs are an important group of post-transcriptional regulators. Numerous literature reports have emphasized that miR-30b plays a crucial role in regulating key signaling pathways. This article collects, collates, and summarizes the literature related to miR-30b in the past 15 years and discusses the relationship between miR-30b and tumor, apoptosis, and drug resistance
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
