Abstract
Aim. Study of the effect of antimicrobial peptides (AMP) on the sensitivity of the conditional pathogenic of bacteria to the action of antagonistic active of representatives mutualistically microflora. Materials and methods. The study used peptides from platelets of chicken obtained by the method of reversed-phase high-performance liquid chromatography in stepwise and linear gradients of increasing concentrations of organic solvent. The effect of AMP on the sensitivity of microorganisms to antagonistic active substances of the dominant bacteria of the genus Lactobacillus, and Enterococcus were investigated in a joint incubation. Antagonistic activity of bacteria studied the gup method. Results. Shown an increased expression of antagonistic activity of indigenous microflora in relation to associative microflora after concubinage with a peptide fractions from platelets of chicken. Conclusion. The obtained results allow to assume the existence of new mechanisms of formation of the colonization resistance of the biotope.
Highlights
The effect of antimicrobial peptides (AMP) on the sensitivity o f mi croorganisms to antagonistic active substances ofthe dominant bacteria ofthe genus Lactobacillus, and Enterococcus were investigated in a joint incubation
Прикладной аспект проведенных исследований заключается в возможности разработки на основе антимикробных пептидов (АМП), выделенных из тромбоцитов курицы домашней, нового перспективного класса антимикробных препаратов, которые могут быть в будущем использованы для терапии инфекционно-воспалительных заболеваний и коррекции дисбиозов
Summary
Aim. Study o f the effect o f antimicrobial peptides (AMP) on the sensitivity o f the conditional pathogenic o f bacteria to the action o f antagonistic active of representatives mutualistically mi croflora. The effect of AMP on the sensitivity o f mi croorganisms to antagonistic active substances ofthe dominant bacteria ofthe genus Lactobacillus, and Enterococcus were investigated in a joint incubation. Спо собных регулировать чувствительность условно патогенных микроорганизмов к антагонистически активным веществам мутуалистической микрофлоры.
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